Table 1 |
|||
|
Assumptions, distributions and sources of model parameters |
|||
|
Parameter |
Mean |
Standard error* |
Source and comments |
|
|
|||
|
Outcomes |
|||
|
Do nothing option |
|||
|
Mortality without CTC (HIV-) |
0.18 |
0.045 |
|
|
Relative risk of death with HIV, no CTC |
2.0 |
0.5 |
[18] SE assumed |
|
Prevalence of HIV in under fives |
0.15 |
0.0375 |
|
|
CTC option |
|||
|
Death rate during CTC |
0.026 |
0.0032 |
Programme data. |
|
Proportion defaulting from CTC |
0.172 |
0.0075 |
Programme data. |
|
Death rate in defaulters from CTC |
0.058 |
0.029 |
Assumed. SE set so 95% CI is +/- 100% of mean |
|
Hospital referral rate from CTC |
0.059 |
0.0047 |
Programme data. |
|
Death rate in hospital |
0.37 |
0.093 |
UTH data. SE assumed |
|
Mortality within a year of recovery |
0.0364 |
0.0091 |
[19] |
|
Expected DALYs if child recovers |
33.3 |
NA |
[5] |
|
Costs (CTC option only) |
|||
|
No. weeks of CTC – recovered |
6.6 |
1.6 |
Programme data. |
|
No. weeks of CTC – referred |
4.8 |
1.1 |
Programme data. |
|
No. weeks of CTC – died |
3.6 |
1.6 |
Programme data. |
|
No. weeks of CTC – defaulted |
5.1 |
1.5 |
Programme data. |
|
Cost per health centre visit |
$4.24 |
$1.06 |
LDMHT. SE assumed. |
|
Cost per kg of RUTF |
$6.10 |
$1.53 |
Valid International. SE assumed. |
|
Kg of RUTF per week per child |
1.90 |
0.016 |
Programme data. |
|
Cost of community mobilisation per child |
$1.06 |
$0.27 |
LDMHT. SE assumed |
|
Valid cost per child |
$68.69 |
$17.17 |
Valid International. SE assumed. |
|
Cost per day in hospital |
$41.35 |
$10.34 |
[24] SE assumed. |
|
Days in hospital |
14 |
3.5 |
UTH data. SE assumed. |
|
|
|||
|
* SE standard errors for probabilistic sensitivity analysis; normal distributions assumed. CI confidence interval. $ international dollars, year 2008. NA not applicable. UTH Lusaka University Teaching Hospital |
|||
|
Bachmann Cost Effectiveness and Resource Allocation 2009 7:2 doi:10.1186/1478-7547-7-2 |
|||
