Table 1 |
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Description of Screening Technologies |
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| Screening Technology |
Test Performance (1) |
Description |
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| Simple Visual Screening |
Sensitivity: 67–79% Specificity: 49–86% |
• Uses acetic acid to reveal acetowhite lesions • For abnormal results, some advocate use with immediate cryotherapy – "see and treat" in a single visit • Does not require special sample collection or laboratory processing equipment • Low level health personnel can be trained to perform • Personnel require supervision and retraining to maintain test performance • Quality Assurance/Quality Control difficult to assess • Generally requires 1–2 patient visits before treatment |
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| Cervical Cytology |
Sensitivity: 47–62% Specificity: 60–95% |
• Cervical smear taken and then sample prepared on slides or in liquid media for transport • Because sample is generally examined in a laboratory, more than one patient visit may be required prior to treatment • Sample collection equipment is minimal, but some laboratory equipment required • Laboratory processing requires trained cytotechnicians and cytopathologists • Human evaluation of samples requires supervision and retraining to maintain test performance • Established Quality Assurance/Quality Control methods exist • Generally requires 3 patient visits before treatment |
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| HPV DNA Testing with Hybrid Capture 2 |
Sensitivity: 66–100% Specificity: 61–96% |
• Cervical sample taken and prepared for transport • Because sample is generally tested in a laboratory, more than one patient visit may be required prior to treatment • Sample collection kit and laboratory equipment required • Laboratory processing is automated requiring fewer personnel resources with less training • Results are quantitative in nature • Established Quality Assurance/Quality Control methods exist • Generally requires 2–3 patient visits before treatment |
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(1) Sankaranarayanan 2005 |
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Goldhaber-Fiebert and Goldie Cost Effectiveness and Resource Allocation 2006 4:13 doi:10.1186/1478-7547-4-13 |
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